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News reports have called DHEA "the mother of all hormones." A new book calls it a "superhormone." On the Internet, it's billed as the "fountain of youth hormone."

In the court of media and public opinion, DHEA is king, a pill that can help us live longer, lose weight or gain it, prevent cancer, heart disease, and Alzheimer's, and combat AIDS and other infectious diseases. The crescendo of praise for this hormone has drowned out the serious cautions that top researchers in the field are raising:

"The one thing you should tell your readers is that we know very little about DHEA. The hype is out of control, and I can't stress enough that it should be used with caution, if at all, until we know more," says Samuel Yen, MD, professor of reproductive medicine at the University of California, San Diego. News reports and advertisements widely cite his studies of people who took DHEA supplements for three months as proof that the hormone "works."
"No one should take DHEA except under the supervision of a physician, who should routinely check steroid and cholesterol levels, glucose tolerance, and prostate health in men," says John Nestle, MD, professor of endocrinology and metabolism at Virginia Commonwealth University, who studies DHEA's effects on diabetes and blood clotting.

"DHEA is the snake oil of the '90s. It makes me very nervous that people are using a drug we don't know anything about. I won't recommend it," says Elizabeth Barrett-Connor, MD, professor and chair, department of family and preventive medicine at the University of California, San Diego. Her studies of natural DHEA levels in older people suggest that higher levels may protect men against heart disease.

"Selling potent steroid hormones in health food stores or by mail could be a disaster in the making. DHEA should be classified as an investigational drug and used only in clinical research until we figure out what it does and its side effects," says Peter Hornsby, PhD, associate professor of cell biology at Baylor College of Medicine. His team has just identified the body's DHEA-making cells.

Why such strong statements from researchers who think DHEA may someday have a medical use? To date, there's no solid proof that DHEA supplements have any real benefit for humans. There's also no proof that they are completely benign. "Unfortunately, we don't see the problems associated with hormone use until years later," says Peter Casson, MD, assistant professor of obstetrics and gynecology at Baylor College of Medicine. He cited as an example the higher of breast cancer in women who took diethylstilbestrol (DES) to prevent a miscarriage, which was discovered only after years of use...

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